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Dr. Shumpei Asamizu, Dr. Satoshi Hirano, Prof. Hiroyasu Onaka, Dr. Hiroyuki Koshino, Dr. Yoshitsugu Shiro and Prof. Shingo Nagano Coupling Reaction of Indolepyruvic Acid by StaD and Its Product: Implications for Biosynthesis of Indolocarbazole and Violacein ChemBioChem 13

Version of Record online: 18 OCT 2012 | DOI: 10.1002/cbic.201200535

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Central C[BOND]C coupling: It has been proposed that the heme-containing enzyme StaD and its homologues catalyze a coupling reaction that yields an indolepyruvic acid (IPA) imine in indolocarbazole biosynthesis. We show that StaD uses IPA enol as an analogue of natural substrate to produce an IPA dimer, in the first direct evidence of the C[BOND]C coupling dimerization reaction catalyzed by StaD.

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