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Kanchan Gupta, Shikha Singh, Kallol Gupta, Naeem Khan, Dr. Devinder Sehgal, Dr. V. Haridas and Dr. Rajendra P. Roy A Bioorthogonal Chemoenzymatic Strategy for Defined Protein Dendrimer Assembly ChemBioChem 13

Version of Record online: 5 OCT 2012 | DOI: 10.1002/cbic.201200559

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Protein dendrimers made easy: We present a chemoenzymatic strategy for the synthesis of well-defined protein dendrimers in which proteins orthogonally labelled by sortase-mediated ligation are conjugated to a dendritic scaffold by azide–alkyne cycloaddition. This “sortase-click” strategy uses readily accessible His6-tagged proteins and can serve as a powerful method for the covalent assembly of multivalent proteins.

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