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Elizabeth Brunk, Dr. Birgit Mollwitz and Prof. Dr. Ursula Rothlisberger Mechanism to Trigger Unfolding in O6-Alkylguanine-DNA Alkyltransferase ChemBioChem 14

Article first published online: 26 MAR 2013 | DOI: 10.1002/cbic.201200566

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Double trouble: In hAGT, a “double-clip” mechanism is used to stabilize the protein in the absence of alkylguanine and to trigger rapid unfolding upon alkyl transfer by creating steric repulsions between S159, M134 and alkylated C145.

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