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John R. Frost, Dr. Francesca Vitali, Nicholas T. Jacob, Micah D. Brown and Prof. Rudi Fasan Macrocyclization of Organo-Peptide Hybrids through a Dual Bio-orthogonal Ligation: Insights from Structure–Reactivity Studies ChemBioChem 14

Version of Record online: 30 NOV 2012 | DOI: 10.1002/cbic.201200579

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Hybrid macrocycles: A novel chemo-biosynthetic strategy for the synthesis of cyclic organo-peptides was shown to be remarkably tolerant of structural variations in both the genetically encoded (black) and synthetic (blue) precursor molecules, thus allowing the efficient construction of functionally and topologically diverse macrocycles. The mechanism underlying the macrocyclization reaction was also elucidated.

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