E-mail a Wiley Online Library Link

John R. Frost, Dr. Francesca Vitali, Nicholas T. Jacob, Micah D. Brown and Prof. Rudi Fasan Macrocyclization of Organo-Peptide Hybrids through a Dual Bio-orthogonal Ligation: Insights from Structure–Reactivity Studies ChemBioChem 14

Version of Record online: 30 NOV 2012 | DOI: 10.1002/cbic.201200579

Thumbnail image of graphical abstract

Hybrid macrocycles: A novel chemo-biosynthetic strategy for the synthesis of cyclic organo-peptides was shown to be remarkably tolerant of structural variations in both the genetically encoded (black) and synthetic (blue) precursor molecules, thus allowing the efficient construction of functionally and topologically diverse macrocycles. The mechanism underlying the macrocyclization reaction was also elucidated.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field