Chad W. Johnston, Rostyslav Zvanych, Nadiya Khyzha and Prof. Nathan A. Magarvey Nonribosomal Assembly of Natural Lipocyclocarbamate Lipoprotein-Associated Phospholipase Inhibitors ChemBioChem 14
Expanding our knowledge: Natural lipocyclocarbamate natural products have provided the inspiration for the first-in-class synthetic phospholipase inhibitor darapladib, currently in phase III clinical trials for the treatment of atherosclerosis. Here, we discuss their biosynthesis by a nonribosomal peptide synthetase.
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