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Chad W. Johnston, Rostyslav Zvanych, Nadiya Khyzha and Prof. Nathan A. Magarvey Nonribosomal Assembly of Natural Lipocyclocarbamate Lipoprotein-Associated Phospholipase Inhibitors ChemBioChem 14

Version of Record online: 10 FEB 2013 | DOI: 10.1002/cbic.201200598

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Expanding our knowledge: Natural lipocyclocarbamate natural products have provided the inspiration for the first-in-class synthetic phospholipase inhibitor darapladib, currently in phase III clinical trials for the treatment of atherosclerosis. Here, we discuss their biosynthesis by a nonribosomal peptide synthetase.

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