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Michael Reinwarth, Bernhard Glotzbach, Michael Tomaszowski, Sebastian Fabritz, Dr. Olga Avrutina and Prof. Dr. Harald Kolmar Oxidative Folding of Peptides with Cystine-Knot Architectures: Kinetic Studies and Optimization of Folding Conditions ChemBioChem 14

Version of Record online: 11 DEC 2012 | DOI: 10.1002/cbic.201200604

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Knotty questions: Oxidative folding of disulfide-rich peptides is still the crucial step in their chemical synthesis as individually tuned conditions are often required. A generic system based on kinetic studies was evaluated and found to give excellent conversion rates in concentrated solutions even for hydrophobic peptides containing multiple thiols with strong aggregation tendencies.

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