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Christian Scheibe, Dr. Stefanie Wedepohl, Sebastian B. Riese, Dr. Jens Dernedde and Prof. Dr. Oliver Seitz Carbohydrate–PNA and Aptamer–PNA Conjugates for the Spatial Screening of Lectins and Lectin Assemblies ChemBioChem 14

Article first published online: 4 JAN 2013 | DOI: 10.1002/cbic.201200618

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Molecular rulers based on PNA–DNA scaffolds were used to control the spatial alignments of mannose, N-acetyllactosamine, sialyl-Lewis-X, and DNA aptamers. The self-assembled complexes served as tools for the spatial screening of the binding sites of lectins and lectin assemblies.

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