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Dr. Erik Prell, Viktoria Kahlert, Dr. Karl Peter Rücknagel, Dr. Miroslav Malešević and Prof. Gunter Fischer Fine Tuning the Inhibition Profile of Cyclosporine A by Derivatization of the MeBmt Residue ChemBioChem 14

Article first published online: 7 DEC 2012 | DOI: 10.1002/cbic.201200621

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Unique respect: The biological properties of four CsA derivatives were fine-tuned by tractable modifications of the MeBmt residue. The new CsA derivatives share strong inhibitory activity toward cyclophilins (Cyps), but each is unique with respect to immunosuppressive action and cellular localization. These CsA analogues can be used to study the physiological roles of extracellular Cyps.

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