Daniela Boettger and Christian Hertweck Molecular Diversity Sculpted by Fungal PKS–NRPS Hybrids ChemBioChem 14
It's all in the mix: The combination of polyketides and amino acids gives rise to a diverse group of secondary metabolites. In fungi, the underlying biosynthetic enzymes code for type I iterative PKS–NRPS hybrids. This review provides an overview of all characterized fungal PKS–NRPS hybrids and their biosynthetic machinery, and highlights molecular engineering approaches.
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