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Mingfeng Yu, Dr. Qun Yu, Dr. Peter J. Rutledge and Dr. Matthew H. Todd A Fluorescent “Allosteric Scorpionand” Complex Visualizes a Biological Recognition Event ChemBioChem 14

Article first published online: 9 JAN 2013 | DOI: 10.1002/cbic.201200637

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A new class of fluorescent metal complex with “ballerina”-like geometry is described. When functionalized with biotin (green) and a dye (orange/red), the zinc(II) complex can be used to visualize interactions with avidin. Metal complexes that can exhibit selective fluorescence changes in response to a macromolecular binding event have great potential for imaging applications.

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