Dr. Edward A. Motea, Prof. Dr. Irene Lee and Prof. Dr. Anthony J. Berdis Insights into the Roles of Desolvation and π-Electron Interactions during DNA Polymerization ChemBioChem 14
Room for errors: HIV-1 reverse transcriptase is remarkable for its low fidelity. This report describes a series of non-natural nucleotides used to explore the biophysical mechanism(s) accounting for error-prone replication catalyzed by this polymerase. This data supports a mechanism highlighting specific interactions of the incoming nucleotide with amino acids capable of mediating hydrogen-bonding interactions.
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