Ning Wang, Dr. Cheng-yuan Huang, Dr. Mizuho Hasegawa, Prof. Dr. Naohiro Inohara, Prof. Dr. Yukari Fujimoto and Prof. Dr. Koichi Fukase Glycan Sequence-Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library ChemBioChem 14
To Nod off or on? Di- or tetrasaccharide fragments of muramidase and glucosamidase were chemically synthesized, and their abilities to stimulate human Nod2 were investigated. The results reveal that hNod2 recognition is glycan sequence-dependent, and suggest that the peptidoglycan degradation process affects the host's immunomodulation.
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