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Dr. Punit P. Seth, Dr. Pradeep S. Pallan, Dr. Eric E. Swayze and Prof. Martin Egli Synthesis, Duplex Stabilization and Structural Properties of a Fluorinated Carbocyclic LNA Analogue ChemBioChem 14

Article first published online: 28 NOV 2012 | DOI: 10.1002/cbic.201200669

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DNA oligonucleotides modified with nucleoside monomers which have an electron withdrawing group (EWG) at the 2′-position of the furanose ring form more stable duplexes with complementary RNA as compared to unmodified DNA. Here we show that an anti-periplanar orientation of the nucleobase and the 2′-EWG is important for optimal duplex stabilization even for nucleic acid analogues with conformationally locked furanose rings.

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