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Dr. Tobias J. Zimmermann, Dr. Sayantani Roy, Nancy E. Martinez, Dr. Slava Ziegler, Dr. Christian Hedberg and Prof. Dr. Herbert Waldmann Biology-Oriented Synthesis of a Tetrahydroisoquinoline-Based Compound Collection Targeting Microtubule Polymerization ChemBioChem 14

Version of Record online: 31 JAN 2013 | DOI: 10.1002/cbic.201200711

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In the third place: Inspired by the tetrahydroisoquinoline (THIQ) alkaloid noscapine, inhibitors of tubulin polymerization that bind to a site different from the colchicine and the vinca alkaloid binding sites have been synthesized. One compound is more potent than noscapine in HeLa cells and can overcome resistance to chemotherapeutics.

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