E-mail a Wiley Online Library Link

Dr. Tobias J. Zimmermann, Dr. Sayantani Roy, Nancy E. Martinez, Dr. Slava Ziegler, Dr. Christian Hedberg and Prof. Dr. Herbert Waldmann Biology-Oriented Synthesis of a Tetrahydroisoquinoline-Based Compound Collection Targeting Microtubule Polymerization ChemBioChem 14

Version of Record online: 31 JAN 2013 | DOI: 10.1002/cbic.201200711

Thumbnail image of graphical abstract

In the third place: Inspired by the tetrahydroisoquinoline (THIQ) alkaloid noscapine, inhibitors of tubulin polymerization that bind to a site different from the colchicine and the vinca alkaloid binding sites have been synthesized. One compound is more potent than noscapine in HeLa cells and can overcome resistance to chemotherapeutics.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field