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Dr. Keya Zhang, Dr. Heng Li, Karan Bhuripanyo, Dr. Bo Zhao, Tiffany F. Chen, Prof. Ning Zheng and Prof. Jun Yin Engineering New Protein–Protein Interactions on the β-Propeller Fold by Yeast Cell Surface Display ChemBioChem 14

Version of Record online: 10 FEB 2013 | DOI: 10.1002/cbic.201200718

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Reinventing the wheel: The β-propeller domain folds like a wheel to provide key protein–protein interactions in the cell. Here we used high-throughput yeast sorting to “invent” β-propellers of new binding specificities with cellular targets.

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