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Nicholas J. Amato and Dr. Amanda C. Bryant-Friedrich The Impact of Structure on Oxidatively Generated DNA Damage Products Resulting from the C3′-Thymidinyl Radical ChemBioChem 14

Version of Record online: 28 DEC 2012 | DOI: 10.1002/cbic.201200723

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What's the damage? Trapping the C3′-thymidinyl radical in biologically significant architectures delivers both the repaired oligomer and 1-(2′-deoxy-β-D-threo-pentofuranosyl)thymidine-containing substrates. The stereoselectivity of the reduction was found to be dependent upon the DNA structure.

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