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Dr. Claudio Iacobucci, Dr. Samantha Reale and Prof. Dr. Francesco De Angelis Photoactivable Amino Acid Bioisosteres and Mass Spectrometry: Snapshots of in Vivo 3D Protein Structures ChemBioChem 14

Version of Record online: 28 DEC 2012 | DOI: 10.1002/cbic.201200742

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From folded to crosslinked proteins. A new promising photo-crosslinking/mass spectrometry method for the structural characterisation of folded proteins is highlighted. A reactive photo-leucine can clamp the front residues in β-turn and β-hairpin domains, thus allowing us to look into the specific native 3D structure of proteins.

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