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Junglim Lee, Dr. Deanne W. Sammond, Zeno Fiorini, Dr. Jonel P. Saludes, Dr. Michael G. Resch, Prof. Dr. Bing Hao, Dr. Wei Wang, Prof. Dr. Hang Yin and Prof. Dr. Xuedong Liu Computationally Designed Peptide Inhibitors of the Ubiquitin E3 Ligase SCFFbx4 ChemBioChem 14

Version of Record online: 11 FEB 2013 | DOI: 10.1002/cbic.201200777

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A structure-based computational approach was used to rationally design peptide inhibitors that can target an E3 ligase (SCFFbx4)–substrate (TRF1) interface and subsequent ubiquitylation. Characterization of the inhibitors demonstrates that our sequence-optimization protocol results in an increase in peptide–TRF1 affinity without compromising peptide–protein specificity.

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