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Dr. Yang Deng, Dr. Brian A. Couch, Prof. Anthony J. Koleske and Prof. Benjamin E. Turk Inside Cover: A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase (ChemBioChem 17/2012) ChemBioChem 13

Article first published online: 17 NOV 2012 | DOI: 10.1002/cbic.201290071

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The inside cover picture shows a peptide photoaffinity label modeled into the active site of the Abl tyrosine kinase. On p. 2510 ff., B. E. Turk et al. show that probes based on Abl substrates label only the active conformation of the kinase. These probes can be used to monitor Abl in complex mixtures and to decipher the mechanisms of action of small-molecule Abl inhibitors.

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