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Prof. Morteza Mahmoudi, Marco P. Monopoli, Meisam Rezaei, Iseult Lynch, Filippo Bertoli, Dr. Jennifer J. McManus and Prof. Kenneth A. Dawson The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation ChemBioChem 14

Article first published online: 18 FEB 2013 | DOI: 10.1002/cbic.201300007

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Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

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