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Dr. Anne Hänchen, Dr. Saskia Rausch, Benjamin Landmann, Dr. Luigi Toti, Antje Nusser and Prof. Dr. Roderich D. Süssmuth Alanine Scan of the Peptide Antibiotic Feglymycin: Assessment of Amino Acid Side Chains Contributing to Antimicrobial Activity ChemBioChem 14

Version of Record online: 27 FEB 2013 | DOI: 10.1002/cbic.201300032

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À la mode scanning: An alanine scan of the peptide antibiotic feglymycin was performed by solution-phase peptide synthesis to assess the significance of individual amino acid side chains for its biological activity. Antibacterial activity against Staphylococcus aureus and the inhibition of enzymes MurA and MurC depend on different amino acids.

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