E-mail

E-mail a Wiley Online Library Link

Dr. Jesko Koehnke, Falk Morawitz, Andrew F. Bent, Dr. Wael E. Houssen, Dr. Sally L. Shirran, Dr. Matthew A. Fuszard, Dr. Iain A. Smellie, Dr. Catherine H. Botting, Prof. Margaret C. M. Smith, Prof. Marcel Jaspars and Prof. James H. Naismith An Enzymatic Route to Selenazolines ChemBioChem 14

Version of Record online: 18 FEB 2013 | DOI: 10.1002/cbic.201300037

Thumbnail image of graphical abstract

Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH