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Jason Ching-Yao Lin, Dr. Chi-Chi Chou, Dr. Shijay Gao, Shang-Chuen Wu, Prof. Kay-Hooi Khoo and Prof. Chun-Hung Lin An in Vivo Tagging Method Reveals that Ras Undergoes Sustained Activation upon Transglutaminase-Mediated Protein Serotonylation ChemBioChem 14

Version of Record online: 16 APR 2013 | DOI: 10.1002/cbic.201300050

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Don't interrupt! Protein serotonylation has been implicated in living cells, yet its role remains poorly defined because of the lack of characterization tools. We synthesized a serotonin derivative to enable selective tagging of serotonylation and to investigate its effect on Ras; the latter displayed undisrupted interaction with Raf-1 at the Ras binding domain.

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