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Yi Zou, Haixing Yin, Dekun Kong, Prof. Dr. Zixin Deng and Prof. Dr. Shuangjun Lin A Trans-Acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248 ChemBioChem 14

Version of Record online: 15 MAR 2013 | DOI: 10.1002/cbic.201300068

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New assembly line, new compound: SIA7248, a new symmetric macrolide, was isolated from a marine-derived Streptomyces strain. Bioinformatic analyses of the identified biosynthetic gene cluster (sia) for SIA7248 suggested a polyketide biosynthesis utilizing an iteratively trans-acting ketoreductase (KR). We characterized SiaM as a trans-KR to catalyse reductions of various β-ketoacyl-thioesters with D-stereospecificity.

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