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Dr. Ben Cowper, Prof. Dr. David J. Craik and Dr. Derek Macmillan Making Ends Meet: Chemically Mediated Circularization of Recombinant Proteins ChemBioChem 14

Article first published online: 4 APR 2013 | DOI: 10.1002/cbic.201300105

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A selective N[RIGHTWARDS ARROW]S acyl transfer reaction facilitates semi-synthesis of the plant cyclotide kalata B1 from a linear precursor peptide of bacterial origin, through simple appendage of N-terminal cysteine and a thiol-labile C-terminal Gly-Cys motif. This constitutes the first synthesis of a ribosomally derived circular miniprotein, without recourse to protein splicing elements.

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