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Akane Hirayama, Prof. Dr. Tadashi Eguchi and Prof. Dr. Fumitaka Kudo A Single PLP-Dependent Enzyme PctV Catalyzes the Transformation of 3-Dehydroshikimate into 3-Aminobenzoate in the Biosynthesis of Pactamycin ChemBioChem 14

Version of Record online: 6 JUN 2013 | DOI: 10.1002/cbic.201300153

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Natural amino donation: A PLP-dependent aminotransferase PctV, encoded in the pactamycin biosynthetic gene cluster, was found to catalyze the formation of 3-aminobenzoate from 3-dehydroshikimate with L-glutamate as the amino donor. The PctV reaction comprises a transamination and two dehydration reactions. This is the first report of a simple 3-ABA synthase in nature.

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