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Jean Christophe Hau, Dr. Dirk Erdmann, Yannick Mesrouze, Dr. Pascal Furet, Patrizia Fontana, Catherine Zimmermann, Dr. Tobias Schmelzle, Dr. Francesco Hofmann and Dr. Patrick Chène The TEAD4–YAP/TAZ Protein–Protein Interaction: Expected Similarities and Unexpected Differences ChemBioChem 14

Article first published online: 18 JUN 2013 | DOI: 10.1002/cbic.201300163

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Hippo pathway functionality: YAP and TAZ are two homologous cofactors that bind with similar affinities to the same binding site on the surface of the TEAD transcription factor, and this might be important for Hippo pathway functionality. However, there are several molecular differences between the binding of YAP and TAZ to TEAD.

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