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Dr. Gerd Nielsen, Dr. Hendrik R. A. Jonker, Dr. Navratna Vajpai, Prof. Dr. Stephan Grzesiek and Prof. Dr. Harald Schwalbe Kinase in Motion: Insights into the Dynamic Nature of p38α by High-Pressure NMR Spectroscopic Studies ChemBioChem 14

Version of Record online: 10 JUL 2013 | DOI: 10.1002/cbic.201300170

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Kinase under pressure: Structural flexibility and the accessibility of excited-energy conformations throughout the structure of activated p38α are probed by a combination of high pressure and NMR spectroscopy. High pressure is shown to induce biologically relevant conformations previously only associated with binding of allosteric DFG-out ligands.

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