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Aleksandra Kapuścik, Dr. Pavel Hrouzek, Dr. Marek Kuzma, Simona Bártová, Dr. Petr Novák, Dr. Jouni Jokela, Maren Pflüger, Dr. Andreas Eger, Dr. Harald Hundsberger and Dr. Jiří Kopecký Novel Aeruginosin-865 from Nostoc sp. as a Potent Anti-inflammatory Agent ChemBioChem 14

Version of Record online: 2 OCT 2013 | DOI: 10.1002/cbic.201300246

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Calm down: Anti-inflammatory activity of the new aeruginosin Aer-865 is reported. In TNF-α-stimulated endothelial cells, Aer-865 downregulates IL-8 and ICAM-1 and is associated with inhibition of NF-κB translocation to the nucleus. In this respect Aer-865 can be considered an interesting immunomodulatory agent.

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