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Dr. Miguel D. Toscano, Dr. Leonardo De Maria, Dr. Sune Lobedanz and Dr. Lars H. Østergaard Optimization of a Small Laccase by Active-Site Redesign ChemBioChem 14

Article first published online: 14 JUN 2013 | DOI: 10.1002/cbic.201300256

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Small but faster: A small laccase from Streptomyces coelicolor (SLAC) has been engineered by structure-based design and site-directed mutagenesis to improve the activity on commercially relevant substrates. The variants generated showed up to 40-fold increased efficiency on 2,6-dimethoxyphenol and the ability to use mediators with considerably higher redox potentials (methylsyringate and TEMPO).

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