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Dr. Yoshiaki Yasutake, Dr. Taiki Nishioka, Dr. Noriko Imoto and Prof. Tomohiro Tamura A Single Mutation at the Ferredoxin Binding Site of P450 Vdh Enables Efficient Biocatalytic Production of 25-Hydroxyvitamin D3 ChemBioChem 14

Version of Record online: 24 SEP 2013 | DOI: 10.1002/cbic.201300386

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Dramatic activity enhancement by a single mutation: A Highly active single mutant of P450 vitamin D3 hydroxylase (Vdh) was obtained by engineering the ferredoxin-binding surface. Biocatalytic production of 25-hydroxyvitamin D3 is reported, by using nisin-treated Rhodococcus erythropolis cells expressing the Vdh mutant.

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