Dr. Yu Qian, Julianne Martell, Nicholas J. Pace, Dr. T. Eric Ballard, Dr. Douglas S. Johnson and Prof. Eranthie Weerapana An Isotopically Tagged Azobenzene-Based Cleavable Linker for Quantitative Proteomics ChemBioChem 14
Putting a number on it: Cleavable linkers are widely utilized in proteomics applications. In particular, the azobenzene-based linker cleaves under mild conditions that are mass-spectrometry-compatible. Here, we adapt this linker for quantitative proteomic applications by incorporating an isotopic label. These light- and heavy-tagged linkers enable the identification and quantitation of labeled peptides from multiple proteomes.
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