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Dr. Zhi-Gang Chen, Monika A Ziętek, Henry J. Russell, Shirley Tait, Dr. Sam Hay, Dr. Alex R. Jones and Prof. Nigel S. Scrutton Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme ChemBioChem 14

Version of Record online: 19 AUG 2013 | DOI: 10.1002/cbic.201300420

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Radical control: A single glutamate residue (E287) in the coenzyme B12-dependent ethanolamine ammonia lyase is pivotal to generating high-energy radical intermediates during catalysis and then controlling the radical chemistry. Using a dynamic, electrostatic mechanism, it helps to guide the radical intermediates towards the desired end by preventing side reactions.

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