Dr. Takayoshi Awakawa, Dr. Xiao-Long Yang, Dr. Toshiyuki Wakimoto and Prof. Dr. Ikuro Abe Pyranonigrin E: A PKS-NRPS Hybrid Metabolite from Aspergillus niger Identified by Genome Mining ChemBioChem 14
Induced production of PKS-NRPS metabolites: The genome mining approach is useful for obtaining new compounds. We activated a dormant PKS-NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.
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