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Dr. Ulrike Krug, Robert Totzauer, Dr. Matthias Zebisch and Prof. Dr. Norbert Sträter The ATP/ADP Substrate Specificity Switch between Toxoplasma gondii NTPDase1 and NTPDase3 is Caused by an Altered Mode of Binding of the Substrate Base ChemBioChem 14

Version of Record online: 2 OCT 2013 | DOI: 10.1002/cbic.201300441

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Reversal of enzyme specificity: Toxoplasma gondii NTPDases1 and -3 vary greatly in their ability to hydrolyze ADP and ATP. Here we show that this switch is mainly dependent on residues 492 and 493, which give rise to two different binding modes of the nucleotide base.

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