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Dr. Shanren Li, Dr. Haoxin Wang, Dr. Yaoyao Li, Jingjing Deng, Dr. Chunhua Lu, Yan Shen and Prof. Dr. Yuemao Shen Biosynthesis of Hygrocins, Antitumor Naphthoquinone Ansamycins Produced by Streptomyces sp. LZ35 ChemBioChem 15

Version of Record online: 25 NOV 2013 | DOI: 10.1002/cbic.201300599

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Highlights of hygrocins: The biosynthesis of hygrocins from Streptomyces sp. LZ35 was elucidated. The luciferase-like monooxygenase (LLM) homologue Hgc3 was identified as a novel Baeyer–Villiger monooxygenase, and P450 monooxygenase Hgc4 was shown to be involved in the 7-hydroxylation step of hygrocins. Additionally, two new intermediates were identified in selected gene disruption mutants.

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