Prof. Morteza Mahmoudi, Marco P. Monopoli, Meisam Rezaei, Iseult Lynch, Filippo Bertoli, Dr. Jennifer J. McManus and Prof. Kenneth A. Dawson Cover Picture: The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation (ChemBioChem 5/2013) ChemBioChem 14
The cover picture shows that the presence of the protein corona at the surface of nanomaterials inhibits the fibrillation process of amyloid beta (Aβ) monomers. Several different nanomaterials [i.e., silica (100 and 200 nm), polystyrene with carboxyl surface modification (100 nm), and multi-walled carbon nanotubes (10–40 nm in diameter and 0.1–10 mm in length)] were used, and their effects on the Aβ fibrillation process were probed in the absence and presence of a protein corona, as well as well as under conditions under whic the protein corona was denatured. In their communication on p. 568 ff., M. Mahmoudi, J. J. McManus, K. A. Dawson, et al. show that the protein corona creates a shell at the surface of nanomaterials, regardless of their physico-chemical properties (e.g., size, core composition, shape, and surface properties), that reduces the levels of Aβ fibril formation.
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