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Stephen A. Cochrane, Dr. Brandon Findlay, Dr. John C. Vederas and Dr. Elaref S. Ratemi Key Residues in Octyl-Tridecaptin A1 Analogues Linked to Stable Secondary Structures in the Membrane ChemBioChem 15

Version of Record online: 9 MAY 2014 | DOI: 10.1002/cbic.201402024

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Just tri it! Analysis of tridecaptin A1 and its octyl analogue have identified key residues responsible for the formation of a stable secondary structure in a model membrane environment. A combination of alanine scanning and CD spectroscopy showed that modification of these residues prevented formation of the secondary structure and abolished antimicrobial activity.

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