Matthew R. Lewin, Philip Bickler, Tom Heier, John Feiner, Lance Montauk and Brett Mensh Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation Clinical Case Reports 1
We describe the reversal of experimental paralysis using nasal spray neostigmine in a healthy human volunteer. The development of a heat-stable, inexpensive antidote to neurotoxins could save lives in the setting of snakebite or other neurotoxic envenomations. Current treatments are generally limited to hospitals and clinics with antivenins and intensive care capabilities. Our findings suggest a novel approach to the treatment of neurotoxic and other snakebites warranting further investigation.
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