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Dr. Kevin M. Jones, Pol Karier and Dr. Martin Klussmann C1-Substituted N-Alkyl Tetrahydroisoquinoline Derivatives through V-Catalyzed Oxidative Coupling ChemCatChem 4

Version of Record online: 14 NOV 2011 | DOI: 10.1002/cctc.201100324

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In the THIQ of it:N-Alkyl tetrahydroisoquinolines are oxidatively coupled with a variety of nucleophiles in the presence of m-CPBA and [VO(acac)2]. This method has been applied to the synthesis of the opioid methopholine.

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