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Vincent Rampazzi, Dr. Alexandre Massard, Dr. Philippe Richard, Dr. Michel Picquet, Prof. Dr. Pierre Le Gendre and Prof. Dr. Jean-Cyrille Hierso A Simple Phosphine–Diolefin-Promoted Copper-Catalysed N-Arylation of Pyrazoles with (Hetero)aromatic Bromides: The Case of Chloroarenes Revisited ChemCatChem 4

Version of Record online: 30 AUG 2012 | DOI: 10.1002/cctc.201200368

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At the copper, coppercubana… A new phosphine–diolefin combined with CuI promotes the coupling of pyrazoles to aryl and heteroaryl C2- and C3-bromides with different functional groups to selectively produce pyridinyl- and pyrimidinyl-pyrazoles, and furyl-, thienyl-, and thiazolyl-substituted pyrazoles. Conversely, for activated chloroarenes, nucleophilic aromatic substitution is achieved without copper or ligand.

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