Dr. Antoine Simonneau, Dr. Youssef Harrak, Louis Jeanne-Julien, Dr. Gilles Lemière, Dr. Virginie Mouriès-Mansuy, Dr. Jean-Philippe Goddard, Prof. Dr. Max Malacria and Prof. Dr. Louis Fensterbank Ring Expansions Within the Gold-Catalyzed Cycloisomerization of O-Tethered 1,6-Enynes. Application to the Synthesis of Natural-Product-like Macrocycles ChemCatChem 5
Goldenyne: O-tethered 1,6-enynes that contain a strained ring at the 3 position can cycloisomerize upon cationic gold(I) catalysis through a ring-expansion process. A two-step sequence allows the transformation of the cyclized compounds into ketomacrolactones, which are reminiscent of natural products.
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