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Dr. Feng Li, Chunlou Sun, Haixia Shan, Xiaoyuan Zou and Jianjiang Xie From Regioselective Condensation to Regioselective N-Alkylation: A Novel and Environmentally Benign Strategy for the Synthesis of N,N′-Alkyl Aryl Ureas and N,N′-Dialkyl Ureas ChemCatChem 5

Article first published online: 9 JAN 2013 | DOI: 10.1002/cctc.201200648

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Watch out, the borrowers are about! N,N′-alkyl aryl ureas and N,N′-dialkyl ureas were synthesized by a transition metal-catalyzed regioselective N3-alkylation of the N-monosubstituted ureas with alcohols. This opens up the design of regioselective N-alkylation of amines with alcohols based on the regioselective condensation of amines with aldehydes, facilitating the progress of the “hydrogen autotransfer” (or “hydrogen-borrowing”)

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