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Yang Zhang, Hélène Jullien, Dr. Delphine Brissy, Dr. Pascal Retailleau, Dr. Arnaud Voituriez and Dr. Angela Marinetti Platinum(II) Catalyzed Enantioselective Cycloisomerizations of 3-Hydroxylated 1,5-Enynes ChemCatChem 5

Article first published online: 25 MAR 2013 | DOI: 10.1002/cctc.201200743

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The cycloisomerization of 1,5-enynes with hydroxyl functions at their propargylic positions was investigated by using NHC-based platinacyclic phosphoramidite complexes as the chiral catalysts. The (R)-Monophos complexes display good catalytic activity in mild conditions. They afford the desired bicyclo[3.1.0]hexan-3-ones in up to 81 % ee from enynes with aryl-substituted alkyne functions.

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