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Dr. Per-Olof Syrén, Florian Le Joubioux, Yesmine Ben Henda, Prof. Thierry Maugard, Prof. Karl Hult and Prof. Marianne Graber Proton Shuttle Mechanism in the Transition State of Lipase-Catalyzed N-Acylation of Amino Alcohols ChemCatChem 5

Version of Record online: 18 FEB 2013 | DOI: 10.1002/cctc.201200751

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Tetrahedra prevailing: An increased reaction rate for lipase-catalyzed N-acylation of amino alcohols and related compounds can be explained by a hydrogen shuttle mechanism that avoids nitrogen inversion in the transition state and favors a tetrahedral intermediate for facile amide bond synthesis.

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