Samuel L. Bourne, Dr. Matthew O'Brien, Sivarajan Kasinathan, Dr. Peter Koos, Dr. Päivi Tolstoy, Dennis X. Hu, Dr. Roderick W. Bates, Dr. Benjamin Martin, Dr. Berthold Schenkel and Prof. Steven V. Ley Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes ChemCatChem 5
Version of Record online: 20 DEC 2012 | DOI: 10.1002/cctc.201200778
Through the telescope: Two tandem flow chemistry processes are developed. A palladium-catalyzed Heck reaction with ethylene gas provides an efficient synthesis for functionalized styrenes. By telescoping this reaction with either a second Heck reaction or a hydroformylation reaction in continuous flow mode, unsymmetrical stilbenes and branched aldehydes are accessed directly from the corresponding aryl iodides.
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