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M. Fatih Polat, Lara Hettmanczyk, Dr. Wei Zhang, Dr. Zoltan Szabo and Dr. Johan Franzén One-Pot, Two-Step Protocol for the Catalytic Asymmetric Synthesis of Optically Active N,O- and O,O-Acetals ChemCatChem 5

Version of Record online: 28 MAR 2013 | DOI: 10.1002/cctc.201200860

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N,O problem: An asymmetric catalytic one-pot N,O- and O,O-acetalization cascade is presented. This strategy is based on catalytic asymmetric conjugate addition and subsequent acid-catalyzed acetal formation that allows efficient and fast construction of functionalized dioxabicyclo- and oxaazabicyclo[3.3.1]nonane structures that are important motifs in several natural products and pharmaceutically interesting compounds.

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