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Lu Chen, Dr. Christian Bruneau, Prof. Pierre H. Dixneuf and Dr. Henri Doucet Palladium-Catalysed Regioselective Direct Arylations of Heteroarenes by Bromobenzamides: Direct Synthesis of Heteroaryl Benzamides ChemCatChem 5

Article first published online: 25 MAR 2013 | DOI: 10.1002/cctc.201200867

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A new sensation in direct arylation: In the presence of KOAc, the Pd-catalyzed direct heteroarylation of 2- or 4-bromobenzamides with heteroarenes proceeds without the formation of C[BOND]N or C[BOND]C bonds by the coupling of two bromobenzamides. With 4-bromobenzamides, both primary and tertiary amides can be employed, whereas only tertiary 2-bromobenzamides were reactive. The nature of the heteroarene had a moderate influence on the reaction. DMAc=N,N-dimethylacetamide.

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