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Dr. Sebastian Bartsch, Gjalt G. Wybenga, Maaike Jansen, Matthew M. Heberling, Dr. Bian Wu, Prof. Bauke W. Dijkstra and Prof. Dick B. Janssen Redesign of a Phenylalanine Aminomutase into a Phenylalanine Ammonia Lyase ChemCatChem 5

Version of Record online: 2 APR 2013 | DOI: 10.1002/cctc.201200871

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The lid dictates: An aminomutase was converted into an ammonia lyase by a rational single-point mutation that destabilizes the closed conformation of the lid covering the active site. The resulting aromatic β-amino acid converting lyase exhibited significantly increased reaction rates (44-fold) and was applied in a preparative-scale asymmetric amination reaction and in kinetic resolution for the production of β-phenylalanine.

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